Characterization of Chicken Tumor Necrosis Factor-α, a Long Missed Cytokine in Birds

Characterization of Chicken Tumor Necrosis Factor-α, a Long Missed Cytokine in Birds

Tumor necrosis factor-α (TNF-α) is a pleiotropic cytokine playing critical roles in host defense and acute and chronic inflammation. It has been described in fish, amphibians, and mammals but was considered to be absent in the avian genomes. Here, we report on the identification and functional chara...

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Bibliographic Details
Main Authors: Franziska Rohde, Benjamin Schusser, Tomáš Hron, Helena Farkašová, Jiří Plachý, Sonja Härtle, Jiří Hejnar, Daniel Elleder, Bernd Kaspers
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
tumor necrosis factor-α
chicken
avian
tumor necrosis factor-α receptors
missing gene
biological activity
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00605/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00605/full

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