Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis

Integrated Omic Analysis Delineates Pathways Modulating Toxic TDP-43 Protein Aggregates in Amyotrophic Lateral Sclerosis

Amyotrophic lateral sclerosis (ALS) is a multi-systemic, incurable, amyloid disease affecting the motor neurons, resulting in the death of patients. The disease is either sporadic or familial with SOD1, C9orf72, FUS, and TDP-43 constituting the majority of familial ALS. Multi-omics studies on patien...

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Bibliographic Details
Main Authors: Saiswaroop Rajaratnam, Akhil P. Soman, Kanikaram Sai Phalguna, Sai Sanwid Pradhan, Meghana Manjunath, Raksha Kanthavara Rao, Rajesh Babu Dandamudi, Sai Krishna Srimadh Bhagavatham, Sujith Kumar Pulukool, Sriram Rathnakumar, Sai Kocherlakota, Ashish Pargaonkar, Ravindra P. Veeranna, Natarajan Arumugam, Abdulrahman I. Almansour, Bibha Choudhary, Venketesh Sivaramakrishnan
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:Cells
Subjects:
ALS
protein aggregates
neurodegenerative disease
transcriptomics
metabolomics
Online Access:https://www.mdpi.com/2073-4409/12/9/1228

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https://www.mdpi.com/2073-4409/12/9/1228

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