Antibody Therapy Targeting CD47 and CD271 Effectively Suppresses Melanoma Metastasis in Patient-Derived Xenografts

Antibody Therapy Targeting CD47 and CD271 Effectively Suppresses Melanoma Metastasis in Patient-Derived Xenografts

The high rate of metastasis and recurrence among melanoma patients indicates the existence of cells within melanoma that have the ability to both initiate metastatic programs and bypass immune recognition. Here, we identify CD47 as a regulator of melanoma tumor metastasis and immune evasion. Protein...

Full description

Bibliographic Details
Main Authors: Michael Ngo, Arum Han, Anita Lakatos, Debashis Sahoo, Stephanie J. Hachey, Kipp Weiskopf, Andrew H. Beck, Irving L. Weissman, Alexander D. Boiko
Format: Article
Language:English
Published: Elsevier 2016-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716308907

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716308907

Similar Items