Cerebrospinal fluid concentrations of fluoroquinolones and carbapenems in tuberculosis meningitis

Cerebrospinal fluid concentrations of fluoroquinolones and carbapenems in tuberculosis meningitis

Background: Tuberculosis meningitis (TBM) is the most lethal form of TB. It is difficult to treat in part due to poor or uncertain drug penetration into the central nervous system (CNS). To help fill this knowledge gap, we evaluated the cerebrospinal fluid (CSF) concentrations of fluoroquinolones an...

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Bibliographic Details
Main Authors: Nicole F. Maranchick, Mohammad H. Alshaer, Alison G. C. Smith, Teona Avaliani, Mariam Gujabidze, Tinatin Bakuradze, Shorena Sabanadze, Zaza Avaliani, Maia Kipiani, Charles A. Peloquin, Russell R. Kempker
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Pharmacology
Subjects:
tuberculosis meningitis
fluoroquinolones
carbapenems
pharmacokinetics
cerebrospinal fluid
antitubercular agents
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.1048653/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.1048653/full

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