Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents

Design, Synthesis, and Biological Evaluation of Novel Biotinylated Podophyllotoxin Derivatives as Potential Antitumor Agents

Podophyllotoxin has long been used as an active substance for cytotoxic activity. Fourteen novel biotinylated podophyllotoxin derivatives were designed, synthesized, and evaluated for cytotoxic activity for this study. The synthesized compounds were evaluated for cytotoxic activity in the following...

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Bibliographic Details
Main Authors: Cheng-Ting Zi, Ying-Sheng Gao, Liu Yang, Shu-Yun Feng, Yue Huang, Li Sun, Yi Jin, Feng-Qing Xu, Fa-Wu Dong, Yan Li, Zhong-Tao Ding, Jun Zhou, Zi-Hua Jiang, Sheng-Tao Yuan, Jiang-Miao Hu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Chemistry
Subjects:
podophyllotoxin derivatives
biotin
anticancer activity
synthesis
apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fchem.2019.00434/full

Internet

https://www.frontiersin.org/article/10.3389/fchem.2019.00434/full

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