Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse

Behavioral and neuropathological characterization over the adult lifespan of the human tau knock-in mouse

Tau is a microtubule-associated protein with a diverse functional repertoire linked to neurodegenerative disease. Recently, a human tau knock-in (MAPT KI) mouse was developed that may overcome many limitations associated with current animal models used to study tau. In MAPT KI mice, the entire murin...

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Bibliographic Details
Main Authors: Matthew J. Benskey, Spencer Panoushek, Takashi Saito, Takaomi C. Saido, Tessa Grabinski, Nicholas M. Kanaan
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-09-01
Series:Frontiers in Aging Neuroscience
Subjects:
tau
MAPT
aging
knock-in mice
glial cells
mouse model
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1265151/full

Internet

https://www.frontiersin.org/articles/10.3389/fnagi.2023.1265151/full

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