Reciprocal Interactions between Fibroblast and Pancreatic Neuroendocrine Tumor Cells: Putative Impact of the Tumor Microenvironment

Reciprocal Interactions between Fibroblast and Pancreatic Neuroendocrine Tumor Cells: Putative Impact of the Tumor Microenvironment

Introduction: Pancreatic neuroendocrine neoplasms (PNENs) present with a fibrotic stroma that constitutes the tumor microenvironment (TME). The role played by stromal fibroblasts in the growth of PNENs and their sensitivity to the mTOR inhibitor RAD001 has not yet been established. Methods: We inves...

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Bibliographic Details
Main Authors: Thomas Cuny, Peter M. van Koetsveld, Grégoire Mondielli, Fadime Dogan, Wouter W. de Herder, Anne Barlier, Leo J. Hofland
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Cancers
Subjects:
neuroendocrine tumor
microenvironment
fibroblasts
cell lines
Online Access:https://www.mdpi.com/2072-6694/14/14/3481

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https://www.mdpi.com/2072-6694/14/14/3481

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