IL-22 Is Deleterious along with IL-17 in Allergic Asthma but Is Not Detrimental in the Comorbidity Asthma and Acute Pneumonia

IL-22 Is Deleterious along with IL-17 in Allergic Asthma but Is Not Detrimental in the Comorbidity Asthma and Acute Pneumonia

There is evidence that IL-22 and IL-17 participate in the pathogenesis of allergic asthma. To investigate the role of IL-22, we used IL-22 deficient mice (IL-22 KO) sensitized and challenged with ovalbumin (OVA) and compared with wild type (WT) animals exposed to OVA. IL-22 KO animals exposed to OVA...

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Bibliographic Details
Main Authors: Amanda Goulart, Mèdéton Mahoussi Michaël Boko, Nubia Sabrina Martins, Ana Flávia Gembre, Rômulo Silva de Oliveira, Sandra Patrícia Palma-Albornoz, Thais Bertolini, Paulo Eduardo Martins Ribolla, Leandra Naira Zambelli Ramalho, Thais Fernanda de Campos Fraga-Silva, Vânia Luiza Deperon Bonato
Format: Article
Language:English
Published: MDPI AG 2023-06-01
Series:International Journal of Molecular Sciences
Subjects:
asthma
IL-22
IL-17
eosinophil
dendritic cell
apoptosis
Online Access:https://www.mdpi.com/1422-0067/24/13/10418

Internet

https://www.mdpi.com/1422-0067/24/13/10418

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