In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens

In silico-guided sequence modifications of K-ras epitopes improve immunological outcome against G12V and G13D mutant KRAS antigens

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Background Somatic point substitution mutations in the KRAS proto-oncogene primarily affect codons 12/13 where glycine is converted into other amino acids, and are highly prevalent in pancreatic, colorectal, and non-small cell lung cancers. These cohorts are non-responsive to anti-EGFR treatments, a...

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Bibliographic Details
Main Authors: Allan Wee Ren Ng, Pei Jun Tan, Winfrey Pui Yee Hoo, Dek Shen Liew, Michelle Yee Mun Teo, Pui Yan Siak, Sze Man Ng, Ee Wern Tan, Raha Abdul Rahim, Renee Lay Hong Lim, Adelene Ai Lian Song, Lionel Lian Aun In
Format: Article
Language:English
Published: PeerJ Inc. 2018-07-01
Series:PeerJ
Subjects:
Mimotope
KRAS
In silico prediction
Immunogen
IEDB
Peptide vaccine
Online Access:https://peerj.com/articles/5056.pdf

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https://peerj.com/articles/5056.pdf

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