Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites

Identification of a non-exported Plasmepsin V substrate that functions in the parasitophorous vacuole of malaria parasites

ABSTRACTMalaria parasites alter multiple properties of the host erythrocyte by exporting proteins into the host cell. Many exported proteins contain a five-amino acid motif called the Plasmodium export element (PEXEL) that is cleaved by the parasite protease Plasmepsin V (PM V). The presence of a PE...

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Bibliographic Details
Main Authors: Aline Fréville, Margarida Ressurreição, Christiaan van Ooij
Format: Article
Language:English
Published: American Society for Microbiology 2024-01-01
Series:mBio
Subjects:
malaria
proteolysis
Plasmodium
protein export
host–parasite relationship
Online Access:https://journals.asm.org/doi/10.1128/mbio.01223-23

Internet

https://journals.asm.org/doi/10.1128/mbio.01223-23

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