Accuracy and data efficiency in deep learning models of protein expression

Abstract Synthetic biology often involves engineering microbial strains to express high-value proteins. Thanks to progress in rapid DNA synthesis and sequencing, deep learning has emerged as a promising approach to build sequence-to-expression models for strain optimization. But such models need lar...

Full description

Bibliographic Details
Main Authors: Evangelos-Marios Nikolados, Arin Wongprommoon, Oisin Mac Aodha, Guillaume Cambray, Diego A. Oyarzún
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34902-5