Interruption of Wnt signaling in Müller cells ameliorates ischemia-induced retinal neovascularization.

Retinal Müller cells are major producers of inflammatory and angiogenic cytokines which contribute to diabetic retinopathy (DR). Over-activation of the Wnt/β-catenin pathway has been shown to play an important pathogenic role in DR. However, the roles of Müller cell-derived Wnt/β-catenin signaling i...

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Bibliographic Details
Main Authors: Kelu Kevin Zhou, Siribhinya Benyajati, Yun Le, Rui Cheng, Wenbo Zhang, Jian-xing Ma
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4182699?pdf=render