NPM1 MUTATED, BCR-ABL1 POSITIVE MYELOID NEOPLASMS: REVIEW OF LITERATURE

NPM1 MUTATED, BCR-ABL1 POSITIVE MYELOID NEOPLASMS: REVIEW OF LITERATURE

Break point cluster region - Abelson (BCR-ABL1) chimeric protein and mutated Nucleophosmin (NPM1) are often present in hematological cancers, but they rarely coexist in the same disease. Both anomalies are considered founder mutations causing inhibition of differentiation and apoptosis, but BCR-ABL1...

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Bibliographic Details
Main Authors: Gianfranco Catalano, Pasquale Niscola, Cristina Banella, Daniela Diverio, Malgorzata Monika Trawinska, Stefano Fratoni, Rita Iazzoni, Paolo de Fabritiis, Elisabetta abruzzese, Nelida Ines Noguera
Format: Article
Language:English
Published: PAGEPress Publications 2020-10-01
Series:Mediterranean Journal of Hematology and Infectious Diseases
Subjects:
NPM1, AML with BCR-ABL1, CML-BP, TKI therapy
Online Access:http://www.mjhid.org/index.php/mjhid/article/view/4384

Internet

http://www.mjhid.org/index.php/mjhid/article/view/4384

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