The RING finger protein family in health and disease

Abstract Ubiquitination is a highly conserved and fundamental posttranslational modification (PTM) in all eukaryotes regulating thousands of proteins. The RING (really interesting new gene) finger (RNF) protein, containing the RING domain, exerts E3 ubiquitin ligase that mediates the covalent attach...

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Bibliographic Details
Main Authors: Chunmei Cai, Yan-Dong Tang, Jingbo Zhai, Chunfu Zheng
Format: Article
Language:English
Published: Nature Publishing Group 2022-08-01
Series:Signal Transduction and Targeted Therapy
Online Access:https://doi.org/10.1038/s41392-022-01152-2