Betulin Acid Ester Derivatives Inhibit Cancer Cell Growth by Inducing Apoptosis through Caspase Cascade Activation: A Comprehensive In Vitro and In Silico Study

Betulin Acid Ester Derivatives Inhibit Cancer Cell Growth by Inducing Apoptosis through Caspase Cascade Activation: A Comprehensive In Vitro and In Silico Study

Betulin, or naturally occurring triterpene, possesses promising antiproliferative activity. To further explore this potential, thirty-eight betulin acid ester derivatives modified at the C-28 position were tested for antitumor activities. Four human cancer cell lines, MV4-11 (leukemia), A549 (lung),...

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Bibliographic Details
Main Authors: Paweł Pęcak, Marta Świtalska, Elwira Chrobak, Grzegorz Boryczka, Ewa Bębenek
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:International Journal of Molecular Sciences
Subjects:
betulin
anticancer activity
apoptosis
caspase 3/7
lipophilicity
ADME
Online Access:https://www.mdpi.com/1422-0067/24/1/196

Internet

https://www.mdpi.com/1422-0067/24/1/196

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