Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis

Paxlovid accelerates cartilage degeneration and senescence through activating endoplasmic reticulum stress and interfering redox homeostasis

Abstract Background The COVID-19 pandemic has become a huge threat to human health, infecting millions of people worldwide and causing enormous economic losses. Many novel small molecule drugs have been developed to treat patients with COVID-19, including Paxlovid, which block the synthesis of virus...

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Bibliographic Details
Main Authors: Keyu Kong, Yongyun Chang, Hua Qiao, Chen Zhao, Xuzhuo Chen, Kewei Rong, Pu Zhang, Minghao Jin, Jingwei Zhang, Huiwu Li, Zanjing Zhai
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Translational Medicine
Subjects:
Paxlovid
COVID-19
Osteoarthritis
Chondrocytes degeneration
Senescence
Online Access:https://doi.org/10.1186/s12967-022-03770-4

Internet

https://doi.org/10.1186/s12967-022-03770-4

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