Preventing ATP Degradation by ASO-Mediated Knockdown of CD39 and CD73 Results in A2aR-Independent Rescue of T Cell Proliferation

Preventing ATP Degradation by ASO-Mediated Knockdown of CD39 and CD73 Results in A2aR-Independent Rescue of T Cell Proliferation

The adenosine axis contributes to the suppression of antitumor immune responses. The ectonucleotidase CD39 degrades extracellular adenosine triphosphate (ATP) to adenosine monophosphate (AMP), which is degraded to adenosine by CD73. Adenosine binds to, e.g., the A2a receptor (A2aR), which reportedly...

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Bibliographic Details
Main Authors: Julia Festag, Tamara Thelemann, Monika Schell, Stefanie Raith, Sven Michel, Frank Jaschinski, Richard Klar
Format: Article
Language:English
Published: Elsevier 2020-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
adenosine axis
ATP
CD39
CD73
ectonucleotidase
A2a receptor
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120301815

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http://www.sciencedirect.com/science/article/pii/S2162253120301815

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