Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in vitro. Here we culture primary human fibroblasts a...

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Bibliographic Details
Main Authors: Gabriel Sturm, Andres Cardenas, Marie-Abèle Bind, Steve Horvath, Shuang Wang, Yunzhang Wang, Sara Hägg, Michio Hirano, Martin Picard
Format: Article
Language:English
Published: Taylor & Francis Group 2019-10-01
Series:Epigenetics
Subjects:
aging
dna methylation
epigenetic age
primary culture
lifespan
accelerated aging
Online Access:http://dx.doi.org/10.1080/15592294.2019.1626651

Internet

http://dx.doi.org/10.1080/15592294.2019.1626651

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