PAD-mediated citrullination is a novel candidate diagnostic marker and druggable target for HPV-associated cervical cancer

PAD-mediated citrullination is a novel candidate diagnostic marker and druggable target for HPV-associated cervical cancer

Citrullination is an emerging post-translational modification catalyzed by peptidyl-arginine deiminases (PADs) that convert peptidyl-arginine into peptidyl-citrulline. In humans, the PAD family consists of five isozymes (PADs 1-4, 6) involved in multiple diseases, including cancer. Given that high-r...

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Bibliographic Details
Main Authors: Camilla Albano, Matteo Biolatti, Jasenka Mazibrada, Selina Pasquero, Francesca Gugliesi, Irene Lo Cigno, Federica Calati, Greta Bajetto, Giuseppe Riva, Gloria Griffante, Santo Landolfo, Marisa Gariglio, Marco De Andrea, Valentina Dell’Oste
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
human papillomaviruses
cervical cancer
citrullination
peptidylarginine deiminases
BB-cl-Amidine
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2024.1359367/full

Internet

https://www.frontiersin.org/articles/10.3389/fcimb.2024.1359367/full

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