The Expanding Role of Cancer Stem Cell Marker ALDH1A3 in Cancer and Beyond

The Expanding Role of Cancer Stem Cell Marker ALDH1A3 in Cancer and Beyond

Aldehyde dehydrogenase 1A3 (ALDH1A3) is one of 19 ALDH enzymes expressed in humans, and it is critical in the production of hormone receptor ligand retinoic acid (RA). We review the role of ALDH1A3 in normal physiology, its identification as a cancer stem cell marker, and its modes of action in canc...

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Bibliographic Details
Main Authors: Meghan E. McLean, Maya R. MacLean, Hannah F. Cahill, Raj Pranap Arun, Olivia L. Walker, Marie-Claire D. Wasson, Wasundara Fernando, Jaganathan Venkatesh, Paola Marcato
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cancers
Subjects:
ALDH1A3
cancer stem cells
chemoresistance
glycometabolism
cell signaling
gene expression
Online Access:https://www.mdpi.com/2072-6694/15/2/492

Internet

https://www.mdpi.com/2072-6694/15/2/492

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