Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.

Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes.

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Short telomeres induce a DNA damage response (DDR) that evokes apoptosis and senescence in human cells. An extant question is the contribution of telomere dysfunction-induced DDR to the phenotypes observed in aging and telomere biology disorders. One candidate is RAP1, a telomere-associated protein...

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Bibliographic Details
Main Authors: Amanda J Stock, Ross A McDevitt, Chandrakala Puligilla, Yajun Wang, Yongqing Zhang, Kun Wang, Chongkui Sun, Kevin G Becker, Elin Lehrmann, William H Wood, Yi Gong, Mohammad Aqdas, Myong-Hee Sung, Victoria Hoffmann, Chengyu Liu, Myriam Gorospe, Lea Harrington, Luigi Ferrucci, Yie Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-11-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010506

Internet

https://doi.org/10.1371/journal.pgen.1010506

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