Statin Increases GTP Cyclohydrolase I mRNA and 5,6,7,8-Tetrahydrobiopterin in Vascular Endothelial Cells

Statin Increases GTP Cyclohydrolase I mRNA and 5,6,7,8-Tetrahydrobiopterin in Vascular Endothelial Cells

We investigated the effects of HMG-CoA reductase inhibitors, so-called statins, on 5,6,7,8-tctrahydrobioptcrin (BH4) metabolism in human umbilical vein endothelial cells (HUVEC). The mRNA of GTP cyclohydrolase I (GTPCH), as well as cNOS, was upregulated in HUVEC treated with cerivastatin. This incre...

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Bibliographic Details
Main Authors: Hattori Yoshiyuki, Nakanishi Nobuo
Format: Article
Language:English
Published: De Gruyter 2006-08-01
Series:Pteridines
Subjects:
statin
nitric oxide
tetrahydrobiopterin
endothelial cells
Online Access:https://doi.org/10.1515/pteridines.2006.17.3.65

Internet

https://doi.org/10.1515/pteridines.2006.17.3.65

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