Transcriptional changes of genes encoding sarcoplasmic reticulum calcium binding and up-taking proteins in normal and Duchenne muscular dystrophy dogs

Transcriptional changes of genes encoding sarcoplasmic reticulum calcium binding and up-taking proteins in normal and Duchenne muscular dystrophy dogs

Abstract Background Cytosolic calcium overload contributes to muscle degradation in Duchenne muscular dystrophy (DMD). The sarcoplasmic reticulum (SR) is the primary calcium storage organelle in muscle. The sarco-endoplasmic reticulum ATPase (SERCA) pumps cytosolic calcium to the SR during muscle re...

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Bibliographic Details
Main Authors: Emily D. Morales, Dongxin Wang, Matthew J. Burke, Jin Han, Drake D. Devine, Keqing Zhang, Dongsheng Duan
Format: Article
Language:English
Published: BMC 2024-10-01
Series:BMC Musculoskeletal Disorders
Subjects:
Duchenne muscular dystrophy
DMD
Canine model
Calcium homeostasis
Gene expression
Sex
Online Access:https://doi.org/10.1186/s12891-024-07927-8

Internet

https://doi.org/10.1186/s12891-024-07927-8

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