Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons

Protective effects of NAMPT or MAPK inhibitors and NaR on Wallerian degeneration of mammalian axons

Wallerian degeneration (WD) is a conserved axonal self-destruction program implicated in several neurological diseases. WD is driven by the degradation of the NAD+ synthesizing enzyme NMNAT2, the buildup of its substrate NMN, and the activation of the NAD+ degrading SARM1, eventually leading to axon...

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Bibliographic Details
Main Authors: Athanasios S. Alexandris, Jiwon Ryu, Labchan Rajbhandari, Robert Harlan, James McKenney, Yiqing Wang, Susan Aja, David Graham, Arun Venkatesan, Vassilis E. Koliatsos
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Neurobiology of Disease
Subjects:
NAD+
Neurodegeneration
Niacin
SARM1
NMNAT2
Neuropathy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996122002005

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http://www.sciencedirect.com/science/article/pii/S0969996122002005

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