Immune Escape in Glioblastoma: Mechanisms of Action and Implications for Immune Checkpoint Inhibitors and CAR T-Cell Therapy

Immune Escape in Glioblastoma: Mechanisms of Action and Implications for Immune Checkpoint Inhibitors and CAR T-Cell Therapy

Glioblastoma, the most common primary brain cancer in adults, is characterized by a poor prognosis and resistance to standard treatments. The advent of immunotherapy has revolutionized the treatment of several cancers in recent years but has failed to demonstrate benefit in patients with glioblastom...

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Bibliographic Details
Main Authors: Catherine Yu, Kristin Hsieh, Daniel R. Cherry, Anthony D. Nehlsen, Lucas Resende Salgado, Stanislav Lazarev, Kunal K. Sindhu
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Biology
Subjects:
glioblastoma
tumor microenvironment
immune checkpoint inhibitors
chimeric antigen receptor (CAR) T-cell therapy
immunotherapy resistance
immunosuppression
Online Access:https://www.mdpi.com/2079-7737/12/12/1528

Internet

https://www.mdpi.com/2079-7737/12/12/1528

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