Geniposide Possesses the Protective Effect on Myocardial Injury by Inhibiting Oxidative Stress and Ferroptosis via Activation of the Grsf1/GPx4 Axis

Geniposide Possesses the Protective Effect on Myocardial Injury by Inhibiting Oxidative Stress and Ferroptosis via Activation of the Grsf1/GPx4 Axis

Reactive oxygen species (ROS) produced in the ischemic myocardium can induce cardiomyocyte injury and death, resulting in cardiac remodeling. Ferroptosis, known as a newly type of cell death caused by iron-dependent oxidative stress, which is an essential death mechanism in cardiomyocytes. However,...

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Bibliographic Details
Main Authors: Yuehong Shen, Xindong Wang, Xinyu Shen, Yue Wang, Shulin Wang, Yunyun Zhang, Xiaoming Yao, Yijiao Xu, Ming Sang, Jiamin Pan, Yu Qin, Qian Zhou, Jianping Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
geniposide
myocardial ischemic injury
oxidative stress
ferroptosis
iron accumulation
lipid peroxidation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.879870/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.879870/full

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