Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE

Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE

SspABCD–SspE is a phosphorothioation-sensing bacterial defence system. Here, authors find that SspE exploits DNA phosphorothioation-binding preference to modulate its biochemical activities for the self/nonself discrimination and phage resistance.

Bibliographic Details
Main Authors: Haiyan Gao, Xinqi Gong, Jinchuan Zhou, Yubing Zhang, Jinsong Duan, Yue Wei, Liuqing Chen, Zixin Deng, Jiawei Wang, Shi Chen, Geng Wu, Lianrong Wang
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34505-0

Internet

https://doi.org/10.1038/s41467-022-34505-0

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