Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE
SspABCD–SspE is a phosphorothioation-sensing bacterial defence system. Here, authors find that SspE exploits DNA phosphorothioation-binding preference to modulate its biochemical activities for the self/nonself discrimination and phage resistance.
Bibliographic Details
| Main Authors: |
Haiyan Gao,
Xinqi Gong,
Jinchuan Zhou,
Yubing Zhang,
Jinsong Duan,
Yue Wei,
Liuqing Chen,
Zixin Deng,
Jiawei Wang,
Shi Chen,
Geng Wu,
Lianrong Wang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-34505-0
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