Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE
SspABCD–SspE is a phosphorothioation-sensing bacterial defence system. Here, authors find that SspE exploits DNA phosphorothioation-binding preference to modulate its biochemical activities for the self/nonself discrimination and phage resistance.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-11-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-34505-0 |
| _version_ | 1798018183992442880 |
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| author | Haiyan Gao Xinqi Gong Jinchuan Zhou Yubing Zhang Jinsong Duan Yue Wei Liuqing Chen Zixin Deng Jiawei Wang Shi Chen Geng Wu Lianrong Wang |
| author_facet | Haiyan Gao Xinqi Gong Jinchuan Zhou Yubing Zhang Jinsong Duan Yue Wei Liuqing Chen Zixin Deng Jiawei Wang Shi Chen Geng Wu Lianrong Wang |
| author_sort | Haiyan Gao |
| collection | DOAJ |
| description | SspABCD–SspE is a phosphorothioation-sensing bacterial defence system. Here, authors find that SspE exploits DNA phosphorothioation-binding preference to modulate its biochemical activities for the self/nonself discrimination and phage resistance. |
| first_indexed | 2024-04-11T16:19:47Z |
| format | Article |
| id | doaj.art-4304db0f6d7a4036ba1165154a9012c4 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-11T16:19:47Z |
| publishDate | 2022-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-4304db0f6d7a4036ba1165154a9012c42022-12-22T04:14:25ZengNature PortfolioNature Communications2041-17232022-11-0113111210.1038/s41467-022-34505-0Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspEHaiyan Gao0Xinqi Gong1Jinchuan Zhou2Yubing Zhang3Jinsong Duan4Yue Wei5Liuqing Chen6Zixin Deng7Jiawei Wang8Shi Chen9Geng Wu10Lianrong Wang11Department of Gastroenterology, TaiKang Center for Life and Medical Sciences, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan UniversityMathematics Intelligence Application Lab, Institute for Mathematical Sciences, Renmin University of ChinaDepartment of Gastroenterology, TaiKang Center for Life and Medical Sciences, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan UniversityDepartment of Gastroenterology, TaiKang Center for Life and Medical Sciences, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan UniversityState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua UniversityDepartment of Gastroenterology, TaiKang Center for Life and Medical Sciences, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan UniversityState Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, The Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong UniversityDepartment of Gastroenterology, TaiKang Center for Life and Medical Sciences, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan UniversityState Key Laboratory of Membrane Biology, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua UniversityDepartment of Gastroenterology, TaiKang Center for Life and Medical Sciences, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan UniversityState Key Laboratory of Microbial Metabolism, School of Life Sciences & Biotechnology, The Joint International Research Laboratory of Metabolic & Developmental Sciences, Shanghai Jiao Tong UniversityDepartment of Gastroenterology, TaiKang Center for Life and Medical Sciences, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences, Wuhan UniversitySspABCD–SspE is a phosphorothioation-sensing bacterial defence system. Here, authors find that SspE exploits DNA phosphorothioation-binding preference to modulate its biochemical activities for the self/nonself discrimination and phage resistance.https://doi.org/10.1038/s41467-022-34505-0 |
| spellingShingle | Haiyan Gao Xinqi Gong Jinchuan Zhou Yubing Zhang Jinsong Duan Yue Wei Liuqing Chen Zixin Deng Jiawei Wang Shi Chen Geng Wu Lianrong Wang Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE Nature Communications |
| title | Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE |
| title_full | Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE |
| title_fullStr | Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE |
| title_full_unstemmed | Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE |
| title_short | Nicking mechanism underlying the DNA phosphorothioate-sensing antiphage defense by SspE |
| title_sort | nicking mechanism underlying the dna phosphorothioate sensing antiphage defense by sspe |
| url | https://doi.org/10.1038/s41467-022-34505-0 |
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