Novel Binding Partners for CCT and PhLP1 Suggest a Common Folding Mechanism for WD40 Proteins with a 7-Bladed Beta-Propeller Structure

Novel Binding Partners for CCT and PhLP1 Suggest a Common Folding Mechanism for WD40 Proteins with a 7-Bladed Beta-Propeller Structure

This study investigates whether selected WD40 proteins with a 7-bladed β-propeller structure, similar to that of the β subunit of the G protein heterotrimer, interact with the cytosolic chaperonin CCT and its known binding partner, PhLP1. Previous studies have shown that CCT is required for the fold...

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Bibliographic Details
Main Authors: Wai Shun Mak, Tsz Ming Tsang, Tsz Yin Chan, Georgi L. Lukov
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Proteomes
Subjects:
WD40
β-propeller
CCT
PhLP1
protein folding
protein motif
Online Access:https://www.mdpi.com/2227-7382/9/4/40

Internet

https://www.mdpi.com/2227-7382/9/4/40

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