Role of the Guanidinium Groups in Ligand–Receptor Binding of Arginine-Containing Short Peptides to the Slow Sodium Channel: Quantitative Approach to Drug Design of Peptide Analgesics

Role of the Guanidinium Groups in Ligand–Receptor Binding of Arginine-Containing Short Peptides to the Slow Sodium Channel: Quantitative Approach to Drug Design of Peptide Analgesics

Several arginine-containing short peptides have been shown by the patch-clamp method to effectively modulate the Na<sub>V</sub>1.8 channel activation gating system, which makes them promising candidates for the role of a novel analgesic medicinal substance. As demonstrated by the organot...

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Bibliographic Details
Main Authors: Vera B. Plakhova, Dmitriy M. Samosvat, Georgy G. Zegrya, Valentina A. Penniyaynen, Arina D. Kalinina, Ma Ke, Svetlana A. Podzorova, Boris V. Krylov, Ilya V. Rogachevskii
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:International Journal of Molecular Sciences
Subjects:
arginine-containing peptides
Na<sub>V</sub>1.8 channel
patch-clamp method
organotypic cell culture method
conformational analysis
nociception
Online Access:https://www.mdpi.com/1422-0067/23/18/10640

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https://www.mdpi.com/1422-0067/23/18/10640

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