GENOMIC EVOLUTION AND RESISTANCE TO PIRTOBRUTINIB IN COVALENT BTK-INHIBITOR PRE-TREATED CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: RESULTS FROM THE PHASE I/II BRUIN STUDY

GENOMIC EVOLUTION AND RESISTANCE TO PIRTOBRUTINIB IN COVALENT BTK-INHIBITOR PRE-TREATED CHRONIC LYMPHOCYTIC LEUKEMIA PATIENTS: RESULTS FROM THE PHASE I/II BRUIN STUDY

Objectives: Pirtobrutinib, a highly selective, non-covalent (reversible) BTKi, demonstrated efficacy in patients (pts) with CLL/SLL who were resistant to cBTKi. Mechanisms of resistance to pirtobrutinib have not been systematically analyzed. We explore the genomic evolution of pirtobrutinib resistan...

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Bibliographic Details
Main Authors: JR Brown, JA Woyach, K Patel, TA Eyre, Cy Cheah, P Ghia, W Jurczak, P Abada, WG Wierda, GFPN Presenter
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Hematology, Transfusion and Cell Therapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2531137923005345

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http://www.sciencedirect.com/science/article/pii/S2531137923005345

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