DEPDC1B promotes development of cholangiocarcinoma through enhancing the stability of CDK1 and regulating malignant phenotypes

DEPDC1B promotes development of cholangiocarcinoma through enhancing the stability of CDK1 and regulating malignant phenotypes

Cholangiocarcinoma (CCA) is the second most common primary tumor of the hepatobiliary system. At present, the therapeutic efficiency of cholangiocarcinoma is fairly low and the prognosis is poor. The root cause is that the molecular mechanism of the occurrence and development of CCA is largely uncle...

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Bibliographic Details
Main Authors: Zhenhai Zhang, Xinxing Wang, Peihua Nie, Yejun Qin, Junping Shi, Shifeng Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Oncology
Subjects:
cholangiocarcinoma
DEPDC1B
CDK1
tumor promotor
ubiquitination
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.842205/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.842205/full

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