IDH1R132H in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis.

IDH1R132H in Neural Stem Cells: Differentiation Impaired by Increased Apoptosis.

BACKGROUND:The high frequency of mutations in the isocitrate dehydrogenase 1 (IDH1) gene in diffuse gliomas indicates its importance in the process of gliomagenesis. These mutations result in loss of the normal function and acquisition of the neomorphic activity converting α-ketoglutarate to 2-hydro...

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Main Authors: Kamila Rosiak, Maciej Smolarz, Wojciech J Stec, Joanna Peciak, Dawid Grzela, Marta Winiecka-Klimek, Ewelina Stoczynska-Fidelus, Barbara Krynska, Sylwester Piaskowski, Piotr Rieske
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4856348?pdf=render

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http://europepmc.org/articles/PMC4856348?pdf=render

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