S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers.
This study examined the value of blood marker S100A1 in detecting cardiotoxicity induced by chemotherapy agents; trastuzumab and lapatinib, in normal rat heart. The rats were divided into three groups: control (n = 8, no treatment), T (n = 8, one time ip treatment with 10 mg/kg trastuzumab) and L (n...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4687715?pdf=render |
| _version_ | 1819237977912508416 |
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| author | Ufuk Eryilmaz Buket Demirci Saliha Aksun Murat Boyacioglu Cagdas Akgullu Tevfik Fikret Ilgenli Hande Sultan Yalinkilinc Mehmet Bilgen |
| author_facet | Ufuk Eryilmaz Buket Demirci Saliha Aksun Murat Boyacioglu Cagdas Akgullu Tevfik Fikret Ilgenli Hande Sultan Yalinkilinc Mehmet Bilgen |
| author_sort | Ufuk Eryilmaz |
| collection | DOAJ |
| description | This study examined the value of blood marker S100A1 in detecting cardiotoxicity induced by chemotherapy agents; trastuzumab and lapatinib, in normal rat heart. The rats were divided into three groups: control (n = 8, no treatment), T (n = 8, one time ip treatment with 10 mg/kg trastuzumab) and L (n = 8, oral treatment with 100 mg/kg/day lapatinib for 7 days). The activities of oxidative stress parameters Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) were measured from the extracted cardiac tissues. The levels of troponinI and S100A1 expressions were measured from blood samples. All biomarkers responded to the treatments as they exhibited alterations from their normative values, validating the chemically induced cardiotoxicity. S100A1 expression attenuated significantly (75%), which made the sensitive detection of cardiotoxicity feasible. Assessment of cardiotoxicity with S100A1 may be a valuable alternative in clinical oncology of cancers in some organs such as breast and prostate, as they do not overexpress it to compete against. |
| first_indexed | 2024-12-23T13:28:54Z |
| format | Article |
| id | doaj.art-43207e0846804b20a2983e983fb2ca67 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-23T13:28:54Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-43207e0846804b20a2983e983fb2ca672022-12-21T17:45:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-011012e014541810.1371/journal.pone.0145418S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers.Ufuk EryilmazBuket DemirciSaliha AksunMurat BoyaciogluCagdas AkgulluTevfik Fikret IlgenliHande Sultan YalinkilincMehmet BilgenThis study examined the value of blood marker S100A1 in detecting cardiotoxicity induced by chemotherapy agents; trastuzumab and lapatinib, in normal rat heart. The rats were divided into three groups: control (n = 8, no treatment), T (n = 8, one time ip treatment with 10 mg/kg trastuzumab) and L (n = 8, oral treatment with 100 mg/kg/day lapatinib for 7 days). The activities of oxidative stress parameters Malondialdehyde (MDA), Superoxide dismutase (SOD), Catalase (CAT) and Glutathione (GSH) were measured from the extracted cardiac tissues. The levels of troponinI and S100A1 expressions were measured from blood samples. All biomarkers responded to the treatments as they exhibited alterations from their normative values, validating the chemically induced cardiotoxicity. S100A1 expression attenuated significantly (75%), which made the sensitive detection of cardiotoxicity feasible. Assessment of cardiotoxicity with S100A1 may be a valuable alternative in clinical oncology of cancers in some organs such as breast and prostate, as they do not overexpress it to compete against.http://europepmc.org/articles/PMC4687715?pdf=render |
| spellingShingle | Ufuk Eryilmaz Buket Demirci Saliha Aksun Murat Boyacioglu Cagdas Akgullu Tevfik Fikret Ilgenli Hande Sultan Yalinkilinc Mehmet Bilgen S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. PLoS ONE |
| title | S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. |
| title_full | S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. |
| title_fullStr | S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. |
| title_full_unstemmed | S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. |
| title_short | S100A1 as a Potential Diagnostic Biomarker for Assessing Cardiotoxicity and Implications for the Chemotherapy of Certain Cancers. |
| title_sort | s100a1 as a potential diagnostic biomarker for assessing cardiotoxicity and implications for the chemotherapy of certain cancers |
| url | http://europepmc.org/articles/PMC4687715?pdf=render |
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