After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism

After virus exposure, early bystander naïve CD8 T cell activation relies on NAD+ salvage metabolism

CD8 T cells play a central role in antiviral immunity. Type I interferons are among the earliest responders after virus exposure and can cause extensive reprogramming and antigen-independent bystander activation of CD8 T cells. Although bystander activation of pre-existing memory CD8 T cells is know...

Full description

Bibliographic Details
Main Authors: Namit Holay, Barry E. Kennedy, J. Patrick Murphy, Prathyusha Konda, Michael Giacomantonio, Tatjana Brauer-Chapin, Joao A. Paulo, Vishnupriyan Kumar, Youra Kim, Mariam Elaghil, Gary Sisson, Derek Clements, Christopher Richardson, Steven P. Gygi, Shashi Gujar
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
antiviral immunity
CD8 T cells
bystander activation
naïve CD8 T cells
type I interferons
immunometabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1047661/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1047661/full

Similar Items