Supplementation with uric and ascorbic acid protects stored red blood cells through enhancement of non-enzymatic antioxidant activity and metabolic rewiring

Supplementation with uric and ascorbic acid protects stored red blood cells through enhancement of non-enzymatic antioxidant activity and metabolic rewiring

Redox imbalance and oxidative stress have emerged as generative causes of the structural and functional degradation of red blood cells (RBC) that happens during their hypothermic storage at blood banks. The aim of the present study was to examine whether the antioxidant enhancement of stored RBC uni...

Full description

Bibliographic Details
Main Authors: Vassilis L. Tzounakas, Alkmini T. Anastasiadi, Vasiliki-Zoi Arvaniti, Veronica Lelli, Giuseppina Fanelli, Efthymios C. Paronis, Anastasia C. Apostolidou, Evangelos G. Balafas, Nikolaos G. Kostomitsopoulos, Effie G. Papageorgiou, Issidora S. Papassideri, Konstantinos Stamoulis, Anastasios G. Kriebardis, Sara Rinalducci, Marianna H. Antonelou
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Redox Biology
Subjects:
RBC storage lesion
Glutathione metabolism
Oxidative stress
Antioxidant supplementation
Uric acid
Ascorbic acid
Online Access:http://www.sciencedirect.com/science/article/pii/S221323172200249X

Internet

http://www.sciencedirect.com/science/article/pii/S221323172200249X

Similar Items