RIP3 knockdown inhibits necroptosis of human intestinal epithelial cells via TLR4/MyD88/NF-κB signaling and ameliorates murine colitis

RIP3 knockdown inhibits necroptosis of human intestinal epithelial cells via TLR4/MyD88/NF-κB signaling and ameliorates murine colitis

Abstract Background Ulcerative colitis (UC) is a common inflammatory bowel disease, during which cell necroptosis plays key roles in driving inflammation initiation and aggravation. Previous studies reported Receptor Interacting Protein Kinase 3 (RIP3)-mediated necroptosis in multiple diseases, and...

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Bibliographic Details
Main Authors: Chaoqin Duan, Xi Xu, Xiaoyi Lu, Ling Wang, Zhongkai Lu
Format: Article
Language:English
Published: BMC 2022-03-01
Series:BMC Gastroenterology
Subjects:
Ulcerative colitis
Nec-1
Necroptosis
Receptor interacting protein kinase 3
TLR4-MyD88
Online Access:https://doi.org/10.1186/s12876-022-02208-x

Internet

https://doi.org/10.1186/s12876-022-02208-x

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