Robustness and parameter geography in post-translational modification systems.

Biological systems are acknowledged to be robust to perturbations but a rigorous understanding of this has been elusive. In a mathematical model, perturbations often exert their effect through parameters, so sizes and shapes of parametric regions offer an integrated global estimate of robustness. He...

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Bibliographic Details
Main Authors: Kee-Myoung Nam, Benjamin M Gyori, Silviana V Amethyst, Daniel J Bates, Jeremy Gunawardena
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2020-05-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1007573