Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus

Sonic Hedgehog Is a Determinant of γδ T-Cell Differentiation in the Thymus

Here we investigate the function of Hedgehog (Hh) signaling in thymic γδ T-cell maturation and subset differentiation. Analysis of Hh mutants showed that Hh signaling promotes γδ T-cell development in the thymus and influences γδ T-cell effector subset distribution. Hh-mediated transcription in thym...

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Bibliographic Details
Main Authors: Konstantinos Mengrelis, Ching-In Lau, Jasmine Rowell, Anisha Solanki, Sonia Norris, Susan Ross, Masahiro Ono, Susan Outram, Tessa Crompton
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-07-01
Series:Frontiers in Immunology
Subjects:
Shh
γδ T-cell
thymus
γδNKT
Smoothened
Hedgehog
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01629/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01629/full

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