Induction of Short NFATc1/αA Isoform Interferes with Peripheral B Cell Differentiation

Induction of Short NFATc1/αA Isoform Interferes with Peripheral B Cell Differentiation

In lymphocytes, immune receptor signals induce the rapid nuclear translocation of preformed cytosolic NFAT proteins. Along with co-stimulatory signals, persistent immune receptor signals lead to high levels of NFATc1/αA, a short NFATc1 isoform, in effector lymphocytes. Whereas NFATc1 is not expresse...

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Bibliographic Details
Main Authors: Khalid Muhammad, Ronald Rudolf, Duong Anh Thuy Pham, Stefan Klein-Hessling, Katsuyoshi Takata, Nobuko Matsushita, Volker Ellenrieder, Eisaku Kondo, Edgar  Serfling
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
B cells
DT40 cells
germinal center
NFATc1
plasmablasts
plasma cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00032/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2018.00032/full

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