Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models

Fisetin, a 3,7,3′,4′-Tetrahydroxyflavone Inhibits the PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models

Psoriasis is a chronic immune-mediated skin disease that involves the interaction of immune and skin cells, and is characterized by cytokine-driven epidermal hyperplasia, deviant differentiation, inflammation, and angiogenesis. Because the available treatments for psoriasis have significant limitati...

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Bibliographic Details
Main Authors: Jean Christopher Chamcheu, Stephane Esnault, Vaqar M. Adhami, Andrea L. Noll, Sergette Banang-Mbeumi, Tithi Roy, Sitanshu S. Singh, Shile Huang, Konstantin G. Kousoulas, Hasan Mukhtar
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cells
Subjects:
fisetin
psoriasis
normal human epidermal keratinocyte
cell signaling
cell differentiation
proliferation
inflammatory cytokine
PBMC
CD4+ T lymphocyte
3D psoriasis-like skin disease model
Online Access:https://www.mdpi.com/2073-4409/8/9/1089

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https://www.mdpi.com/2073-4409/8/9/1089

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