The Effects of Acute and Chronic Selective Phosphodiesterase 1 Inhibition on Smooth Muscle Cell-Associated Aging Features

The Effects of Acute and Chronic Selective Phosphodiesterase 1 Inhibition on Smooth Muscle Cell-Associated Aging Features

Age-related cardiovascular diseases (CVDs) remain among the leading global causes of death, and vascular smooth muscle cell (VSMC) remodeling plays an essential role in its pathology. Reduced NO-cGMP pathway signaling is a major feature and pathogenic mechanism underlying vasodilator dysfunction. Re...

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Bibliographic Details
Main Authors: Keivan Golshiri, Ehsan Ataei Ataabadi, Annika A. Jüttner, Gretchen L. Snyder, Robert E Davis, Amy Lin, Lei Zhang, René de Vries, Ingrid M Garrelds, Frank P. J. Leijten, A. H. Jan Danser, Anton J. M. Roks
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Pharmacology
Subjects:
phosphodiesterase
vascular aging
smooth muscle cell
cardiovascular
NO-cGMP pathway
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.818355/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.818355/full

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