The Downregulation of Both Giant HERCs, <i>HERC1</i> and <i>HERC2</i>, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation

The Downregulation of Both Giant HERCs, <i>HERC1</i> and <i>HERC2</i>, Is an Unambiguous Feature of Chronic Myeloid Leukemia, and HERC1 Levels Are Associated with Leukemic Cell Differentiation

Large HERC E3 ubiquitin ligase family members, <i>HERC1</i> and <i>HERC2</i>, are staggeringly complex proteins that can intervene in a wide range of biological processes, such as cell proliferation, DNA repair, neurodevelopment, and inflammation. Therefore, mutations or dysr...

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Bibliographic Details
Main Authors: Muhammad Shahzad Ali, Stefano Magnati, Cristina Panuzzo, Daniela Cilloni, Giuseppe Saglio, Barbara Pergolizzi, Enrico Bracco
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Journal of Clinical Medicine
Subjects:
ubiquitin system
large HERCs
TKIs
CML
differentiation
Online Access:https://www.mdpi.com/2077-0383/11/2/324

Internet

https://www.mdpi.com/2077-0383/11/2/324

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