The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells

The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells

Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate carboxylase, thereby inhibiting insulin secretio...

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Bibliographic Details
Main Authors: Xiaomu Li, Kenneth K. Y. Cheng, Zhuohao Liu, Jin-Kui Yang, Baile Wang, Xue Jiang, Yawen Zhou, Philip Hallenborg, Ruby L. C. Hoo, Karen S. L. Lam, Yasuhiro Ikeda, Xin Gao, Aimin Xu
Format: Article
Language:English
Published: Nature Portfolio 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11740

Internet

https://doi.org/10.1038/ncomms11740

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