The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells
Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate carboxylase, thereby inhibiting insulin secretio...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11740 |
| _version_ | 1819040309697314816 |
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| author | Xiaomu Li Kenneth K. Y. Cheng Zhuohao Liu Jin-Kui Yang Baile Wang Xue Jiang Yawen Zhou Philip Hallenborg Ruby L. C. Hoo Karen S. L. Lam Yasuhiro Ikeda Xin Gao Aimin Xu |
| author_facet | Xiaomu Li Kenneth K. Y. Cheng Zhuohao Liu Jin-Kui Yang Baile Wang Xue Jiang Yawen Zhou Philip Hallenborg Ruby L. C. Hoo Karen S. L. Lam Yasuhiro Ikeda Xin Gao Aimin Xu |
| author_sort | Xiaomu Li |
| collection | DOAJ |
| description | Mice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate carboxylase, thereby inhibiting insulin secretion. |
| first_indexed | 2024-12-21T09:07:03Z |
| format | Article |
| id | doaj.art-433046fc179446af96ac4977f8bb7b86 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-21T09:07:03Z |
| publishDate | 2016-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-433046fc179446af96ac4977f8bb7b862022-12-21T19:09:19ZengNature PortfolioNature Communications2041-17232016-06-017111410.1038/ncomms11740The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cellsXiaomu Li0Kenneth K. Y. Cheng1Zhuohao Liu2Jin-Kui Yang3Baile Wang4Xue Jiang5Yawen Zhou6Philip Hallenborg7Ruby L. C. Hoo8Karen S. L. Lam9Yasuhiro Ikeda10Xin Gao11Aimin Xu12State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongBeijing Key Laboratory of Diabetes Research and Care, Beijing Tongren Hospital, Capital Medical UniversityState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongDepartment of Biochemistry and Molecular Biology, University of Southern DenmarkState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongDepartment of Molecular Medicine, Mayo ClinicDepartment of Endocrinology and Metabolism, Zhongshan Hospital, Fudan UniversityState Key Laboratory of Pharmaceutical Biotechnology, The University of Hong KongMice lacking the tumour suppressor p53 are partially protected from developing diabetes. Here the authors show that p53 is upregulated in the pancreas of diabetic mice where it impairs β cell function by repressing expression of mitochondrial pyruvate carboxylase, thereby inhibiting insulin secretion.https://doi.org/10.1038/ncomms11740 |
| spellingShingle | Xiaomu Li Kenneth K. Y. Cheng Zhuohao Liu Jin-Kui Yang Baile Wang Xue Jiang Yawen Zhou Philip Hallenborg Ruby L. C. Hoo Karen S. L. Lam Yasuhiro Ikeda Xin Gao Aimin Xu The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells Nature Communications |
| title | The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| title_full | The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| title_fullStr | The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| title_full_unstemmed | The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| title_short | The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells |
| title_sort | mdm2 p53 pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose stimulated insulin secretion in pancreatic β cells |
| url | https://doi.org/10.1038/ncomms11740 |
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