Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway

Secreted frizzled-related protein 5 (SFRP5) protects ATDC5 cells against LPS-induced inflammation and apoptosis via inhibiting Wnt5a/JNK pathway

Abstract Background Secreted frizzled-related protein 5 (SFRP5) is an endogenous inhibitor of Wnt5a (wingless-type family member 5a), which has been implicated in anti-inflammatory response. In this study, we aimed to investigate whether SFRP5 could protect chondrocytes against LPS-induced inflammat...

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Bibliographic Details
Main Authors: Minghui Sun, Weijun Wang, Lingtian Min, Cheng Chen, Qing Li, Wenjie Weng
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
C-Jun N-terminal kinase
Inflammation
Osteoarthritis
Secreted frizzled-related protein 5
Wnt5a
Online Access:https://doi.org/10.1186/s13018-021-02260-5

Internet

https://doi.org/10.1186/s13018-021-02260-5

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