Modified Dendritic cell-based T-cell expansion protocol and single-cell multi-omics allow for the selection of the most expanded and in vitro-effective clonotype via profiling of thousands of MAGE-A3-specific T-cells

Modified Dendritic cell-based T-cell expansion protocol and single-cell multi-omics allow for the selection of the most expanded and in vitro-effective clonotype via profiling of thousands of MAGE-A3-specific T-cells

IntroductionAdoptive cell therapy using TCR-engineered T-cells is one of the most effective strategies against tumor cells. The TCR T-cell approach has been well tested against a variety of blood neoplasms but is yet to be deeply tested against solid tumors. Among solid tumors, cancer-testis antigen...

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Bibliographic Details
Main Authors: Sergey Sennikov, Marina Volynets, Saleh Alrhmoun, Roman Perik-Zavodskii, Olga Perik-Zavodskaia, Marina Fisher, Julia Lopatnikova, Julia Shevchenko, Kirill Nazarov, Julia Philippova, Alaa Alsalloum, Vasily Kurilin, Alexander Silkov
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Immunology
Subjects:
MAGE-A3
ScRNA-seq
scTCR-seq
TCR
T-cell receptor repertoire
TCR T-cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1470130/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1470130/full

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