Determination of lethal electric field threshold for pulsed field ablation in ex vivo perfused porcine and human hearts

IntroductionPulsed field ablation is an emerging modality for catheter-based cardiac ablation. The main mechanism of action is irreversible electroporation (IRE), a threshold-based phenomenon in which cells die after exposure to intense pulsed electric fields. Lethal electric field threshold for IRE...

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Bibliographic Details
Main Authors: Bor Kos, Lars Mattison, David Ramirez, Helena Cindrič, Daniel C. Sigg, Paul A. Iaizzo, Mark T. Stewart, Damijan Miklavčič
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1160231/full