Production of Atosiban’s Key Intermediate Pentapeptide: Synthetic Approaches to the Development of a Peptide Synthesis with Less Racemization and Simplifier Purification Process
The key intermediate NH<sub>2</sub>-Ile-Thr(Bzl)-Asn-Cys(Bzl)-Pro-COOH of Atosiban was prepared from <i>N</i>-Boc-<i>S</i>-Bzl-cysteine by the stepwise lengthening of the chain according to the repetitive <i>N</i>,<i>O</i>-bis(trimethylsily...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2022-03-01
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Series: | Molecules |
Subjects: | |
Online Access: | https://www.mdpi.com/1420-3049/27/6/1920 |
Summary: | The key intermediate NH<sub>2</sub>-Ile-Thr(Bzl)-Asn-Cys(Bzl)-Pro-COOH of Atosiban was prepared from <i>N</i>-Boc-<i>S</i>-Bzl-cysteine by the stepwise lengthening of the chain according to the repetitive <i>N</i>,<i>O</i>-bis(trimethylsilyl)acetamide/<i>N</i>-hydroxysuccinimide ester (BSA/NHS) strategy. This synthetic route required no chromatography purification and can be readily performed, yielding a highly pure pentapeptide compound. |
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ISSN: | 1420-3049 |